Beilstein J. Org. Chem.2020,16, 190–199, doi:10.3762/bjoc.16.22
: DFT; F···Hhydrogenbond; fluorinated phenylcoumarin; Pechmann reaction; through-space coupling; Introduction
Coumarins constitute one of the big classes of naturally occurring compounds. The first coumarin was isolated from the tonka bean (Dipteryx odorata) in 1820 and, to date, more than 1300
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Graphical Abstract
Scheme 1:
Synthesis of 4-(2-fluorophenyl)-7-methoxycoumarin (6).